Cardiorespiratory distress after sumatriptan given by injection

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Evidence against strong correlation between chest symptoms and ischemic coronary changes after subcutaneous sumatriptan injection.

OBJECTIVE To evaluate the adverse events possibly caused by sumatriptan injection and explore the relationship between chest symptoms along with sumatriptan injection and coronary ischemia among Japanese patients with migraine. METHODS A cumulative total of 112 subcutaneous injections in 62 patients were evaluated. ECG was continuously monitored before and until 5 minutes after injection on 9...

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1. The 5-hydroxytryptamine (5-HT1)-like agonist, sumatriptan, is highly efficient in the relief of migraine headache and its accompanying symptoms. 2. Experimental evidence has indicated that its site of action may be on the cranial vessels or on the trigeminal innervation of the cranium, or both, since sumatriptan does not pass the blood-brain barrier easily under normal circumstances. It is, ...

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ژورنال

عنوان ژورنال: BMJ

سال: 1992

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.305.6855.714-a