Cardiorespiratory distress after sumatriptan given by injection

Evidence against strong correlation between chest symptoms and ischemic coronary changes after subcutaneous sumatriptan injection.

OBJECTIVE To evaluate the adverse events possibly caused by sumatriptan injection and explore the relationship between chest symptoms along with sumatriptan injection and coronary ischemia among Japanese patients with migraine. METHODS A cumulative total of 112 subcutaneous injections in 62 patients were evaluated. ECG was continuously monitored before and until 5 minutes after injection on 9...

Sumatriptan ameliorates renal injury induced by cisplatin in mice

Objective(s): Cisplatin (Cis) is an anticancer compound, which is used for the treatment of various cancers. Sumatriptan (Suma) is a selective agonist of 5-hydroxytryptamine 1B/1D (5HT1B/1D) receptor, which is prescribed for the management of migraine. It is well-established that Suma has anti-inflammatory and antioxidant properties. We have explored the protective effe...

Psychological distress after stroke.

Letters Psychological distress after stroke Sir: Various studies have reported the presence of depression in patients affected by stroke; the prevalence rates found in most such research range from 30% to 60%.'-3 However, less data are available on the presence of other types of psychological distress in such patients. The purpose of this investigation was to evaluate the presence of both depre...

Inhibition by sumatriptan of central trigeminal neurones only after blood-brain barrier disruption.

1. The 5-hydroxytryptamine (5-HT1)-like agonist, sumatriptan, is highly efficient in the relief of migraine headache and its accompanying symptoms. 2. Experimental evidence has indicated that its site of action may be on the cranial vessels or on the trigeminal innervation of the cranium, or both, since sumatriptan does not pass the blood-brain barrier easily under normal circumstances. It is, ...

Cardiorespiratory arrest after administration of an antibiotic.